SnapGene ' acgcgtgtagtcttatgcaatactcttgtagtcttgcaacatggtaacgatgagttagcaacatgccttacaaggagagaaaaagcaccgtgcatgccgattggtggaagtaaggtggtacgatcgtgccttattaggaaggcaacagacgggtctgacatggattggacgaaccactgaattgccgcattgcagagatattgtatttaagtgcctagctcgatacaataaacgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtggcgcccgaacagggacctgaaagcgaaagggaaaccagagctctctcgacgcaggactcggcttgctgaagcgcgcacggcaagaggcgaggggcggcgactggtgagtacgccaaaaattttgactagcggaggctagaaggagagagatgggtgcgagagcgtcagtattaagcgggggagaattagatcgcgatgggaaaaaattcggttaaggccagggggaaagaaaaaatataaattaaaacatatagtatgggcaagcagggagctagaacgattcgcagttaatcctggcctgttagaaacatcagaaggctgtagacaaatactgggacagctacaaccatcccttcagacaggatcagaagaacttagatcattatataatacagtagcaaccctctattgtgtgcatcaaaggatagagataaaagacaccaaggaagctttagacaagatagaggaagagcaaaacaaaagtaagaccaccgcacagcaagcggccactgatcttcagacctggaggaggagatatgagggacaattggagaagtgaattatataaatataaagtagtaaaaattgaaccattaggagtagcacccaccaaggcaaagagaagagtggtgcagagagaaaaaagagcagtgggaataggagctttgttccttgggttcttgggagcagcaggaagcactatgggcgcagcctcaatgacgctgacggtacaggccagacaattattgtctggtatagtgcagcagcagaacaatttgctgagggctattgaggcgcaacagcatctgttgcaactcacagtctggggcatcaagcagctccaggcaagaatcctggctgtggaaagatacctaaaggatcaacagctcctggggatttggggttgctctggaaaactcatttgcaccactgctgtgccttggaatgctagttggagtaataaatctctggaacagattggaatcacacgacctggatggagtgggacagagaaattaacaattacacaagcttaatacactccttaattgaagaatcgcaaaaccagcaagaaaagaatgaacaagaattattggaattagataaatgggcaagtttgtggaattggtttaacataacaaattggctgtggtatataaaattattcataatgatagtaggaggcttggtaggtttaagaatagtttttgctgtactttctatagtgaatagagttaggcagggatattcaccattatcgtttcagacccacctcccaaccccgaggggacccgacaggcccgaaggaatagaagaagaaggtggagagagagacagagacagatccattcgattagtgaacggatctcgacggttaacttttaaaagaaaaggggggattggggggtacagtgcaggggaaagaatagtagacataatagcaacagacatacaaactaaagaattacaaaaacaaattacaaaaattcaaaattttatcgatactagtattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagattctagagctagcgaattcgccaccatggaagtccagtgcggtggtgcggggttcatcccagaaagttcaaggagcagccatgagcttggaaaccaagatcaaggaattccccaactgagaattgtcttacttggaaaaactggagcaggaaagagttcaacagggaacagtatccttggggaaaaagtgtttaattctggcatttgtgcaaaatccatcaccaaggtctgtgaaaaaagggtgagcacctgggatgggaaagagcttgttgtcgtggatacacctggtatttttgacactgaggtaccagatgctgacacacaaagggagatcactcgctatgttgccctgacctctccagggcctcatgctctgctcctggtagttccactggggcgttatactgtggaagaacacaaggctacacagaaaattctggacatgtttggaaaacaggctagaagattcatgattctcttgctcaccaggaaggatgacttagaagacactgatatccatgagtacttagagaaggctcctaaattctttcaagaggtgatgcatgagttccagaatcgctactgtttgttcaacaacagagcctcaggcgctgaaaaggaagagcagaagatgcaattgttgaccttggtccagagcatggtgagggaaaatggtggaagatgctttactaataagatgtatgaaagtgccgagtgtgtgatccagaaagagaccttgaggatgcaagaattatacagagaggagctagagagggagaaagcacggataagacgggagtatgaagaacagattaaagatctgagagatgaactggagagggaaataagaagggcacgtatggagagggaattcaaggagagggaggctatctttacaaagaatcaacaaaatgctaggaaggaagttgagaacacaagtatgatacttgaattaattataaaagcatgggagattgcttcctttatcttcaaccagtttatgaaagacCTCGAGGACTACAAAGACCATGACGGTGATTATAAAGATCATGACATCGACTACAAGGATGACGATGACAAGtaaggatccgcggccgcaaggatctgcgatcgctccggtgcccgtcagtgggcagagcgcacatcgcccacagtccccgagaagttggggggaggggtcggcaattgaacgggtgcctagagaaggtggcgcggggtaaactgggaaagtgatgtcgtgtactggctccgcctttttcccgagggtgggggagaaccgtatataagtgcagtagtcgccgtgaacgttctttttcgcaacgggtttgccgccagaacacagctgaagcttcgaggggctcgcatctctccttcacgcgcccgccgccctacctgaggccgccatccacgccggttgagtcgcgttctgccgcctcccgcctgtggtgcctcctgaactgcgtccgccgtctaggtaagtttaaagctcaggtcgagaccgggcctttgtccggcgctcccttggagcctacctagactcagccggctctccacgctttgcctgaccctgcttgctcaactctacgtctttgtttcgttttctgttctgcgccgttacagatccaagctgtgaccggcgcctacgctagacgccaccatggagagcgacgagagcggcctgatggaagacgccaaaaacataaagaaaggcccggcgccattctatccgctggaagatggaaccgctggagagcaactgcataaggctatgaagagatacgccctggttcctggaacaattgcttttacagatgcacatatcgaggtggacatcacttacgctgagtacttcgaaatgtccgttcggttggcagaagctatgaaacgatatgggctgaatacaaatcacagaatcgtcgtatgcagtgaaaactctcttcaattctttatgccggtgttgggcgcgttatttatcggagttgcagttgcgcccgcgaacgacatttataatgaacgtgaattgctcaacagtatgggcatttcgcagcctaccgtggtgttcgtttccaaaaaggggttgcaaaaaattttgaacgtgcaaaaaaagctcccaatcatccaaaaaattattatcatggattctaaaacggattaccagggatttcagtcgatgtacacgttcgtcacatctcatctacctcccggttttaatgaatacgattttgtgccagagtccttcgatagggacaagacaattgcactgatcatgaactcctctggatctactggtctgcctaaaggtgtcgctctgcctcatagaactgcctgcgtgagattctcgcatgccagagatcctatttttggcaatcaaatcattccggatactgcgattttaagtgttgttccattccatcacggttttggaatgtttactacactcggatatttgatatgtggatttcgagtcgtcttaatgtatagatttgaagaagagctgtttctgaggagccttcaggattacaagattcaaagtgcgctgctggtgccaaccctattctccttcttcgccaaaagcactctgattgacaaatacgatttatctaatttacacgaaattgcttctggtggcgctcccctctctaaggaagtcggggaagcggttgccaagaggttccatctgccaggtatcaggcaaggatatgggctcactgagactacatcagctattctgattacacccgagggggatgataaaccgggcgcggtcggtaaagttgttccattttttgaagcgaaggttgtggatctggataccgggaaaacgctgggcgttaatcaaagaggcgaactgtgtgtgagaggtcctatgattatgtccggttatgtaaacaatccggaagcgaccaacgccttgattgacaaggatggatggctacattctggagacatagcttactgggacgaagacgaacacttcttcatcgttgaccgcctgaagtctctgattaagtacaaaggctatcaggtggctcccgctgaattggaatccatcttgctccaacaccccaacatcttcgacgcaggtgtcgcaggtcttcccgacgatgacgccggtgaacttcccgccgccgttgttgttttggagcacggaaagacgatgacggaaaaagagatcgtggattacgtcgccagtcaagtaacaaccgcgaaaaagttgcgcggaggagttgtgtttgtggacgaagtaccgaaaggtcttaccggaaaactcgacgcaagaaaaatcagagagatcctcataaaggccaagaagggcggaaagatcgccgtgagatcccgcgctcagtcgtccaattctgccgtggacggcaccgccggacccggctccaccggatctcgcgagggcagaggaagtcttctaacatgcggtgacgtggaggagaatcccggccctatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgaaatcaacctctggattacaaaatttgtgaaagattgactggtattcttaactatgttgctccttttacgctatgtggatacgctgctttaatgcctttgtatcatgctattgcttcccgtatggctttcattttctcctccttgtataaatcctggttgctgtctctttatgaggagttgtggcccgttgtcaggcaacgtggcgtggtgtgcactgtgtttgctgacgcaacccccactggttggggcattgccaccacctgtcagctcctttccgggactttcgctttccccctccctattgccacggcggaactcatcgccgcctgccttgcccgctgctggacaggggctcggctgttgggcactgacaattccgtggtgttgtcggggaagctgacgtcctttccatggctgctcgcctgtgttgccacctggattctgcgcgggacgtccttctgctacgtcccttcggccctcaatccagcggaccttccttcccgcggcctgctgccggctctgcggcctcttccgcgtctccgccttcgccctcagacgagtcggatctccctttggccgcctccccgcctggtacctttaagaccaatgacttacaaggcagctgtagatcttagccactttttaaaagaaaaggggggactggaagggctaattcactcccaacgaaaataagatctgctttttgcttgtactgggtctctctggttagaccagatctgagcctgggagctctctggctaactagggaacccactgcttaagcctcaataaagcttgccttgagtgcttcaagtagtgtgtgcccgtctgttgtgtgactctggtaactagagatccctcagacccttttagtcagtgtggaaaatctctagcagtagtagttcatgtcatcttattattcagtatttataacttgcaaagaaatgaatatcagagagtgagaggaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggctctagctatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctcggcctctgagctattccagaagtagtgaggaggcttttttggaggcctagacttttgcagagacggcccaaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggcgccattcgccattcaggctgcgcaactgttgggaagggcgatcggtgcgggcctcttcgctattacgccagctggcgaaagggggatgtgctgcaaggcgattaagttgggtaacgccagggttttcccagtcacgacgttgtaaaacgacggccagtgccaagctg U 2 > ) : L 2 7 % 2 # . * 4 E % 1 F E ( ( ! " ) 2 , & $ 2 % ( . # 4 ) $ $ / 2 4 6 5 " ( < 0 0 8 ( 2 6 2 G G 9 ) + ) ( ! 2 1 D J , - L r 7 $ ( 8 , * & , * + 0 & ) 1 ( ' % * 2 # + ! $ & / B 2 ) - 0 . 0 - ) / 4 # . $ ( " ( - # - 3 ( 1 ! . ) ? ' $ & ( - ( - ( % % 9 + ) + ( ( " - ) !
# ( $ - K * > ) ( 6 4 * ' ! ) ) G 0 % + # / + . 1 4 ) E . $ $ ( / / ( 1 2 QR}~ % * h
n
o
p
u
)9XY+:BCD t !$%&''> Sf-K {+ +G %
x & A P q
L:l;tEG u !">#$v%&m'' 8C& v
, !P%%%&&'') `uH
i
2 I
*Bl)Z O < ""$~%&&r'': I #.T4L[=,& m &
! < K Q r
Z\$svJMI<b| v "&&:'L i g]r.U0Oku,7 F d s w
I y ' B t x
rU2;.+90<K% y H ' *!!"?#$_%w%%n'2
G |
+
7CM*gvfIMH i !!!$$%&' H
m%? uF 7 f q 9
s <
Bq4^-1 ~ $ ]!#`$Q%m&v&&& 'z' * t jx E y
\
Z m !6!W!#'% rD'I c(zOAL O ~ `!## $%%' g w
: * !!3"##&2 av}j
>
B!,7[~{ @ #$$$%J&&&L's'''# w8 3 J
{
,a*v E!R"|#&$c%&. &@
T
+CmQ bg/QP 4 N = ""#&&^'* x~I
#
SjWny jQ W ` i " 4 " # $V&''4 $p>
v $ ? N R s
'QJ t'.K`w O U z } y | P""T&E J L r/13>UL T '
" = L f
[d u]@NJh= o u w !"y$%&';'% 3 A
\q-x
g}wc}cq | 1!)"G##c$$'1
@v&5M' 1 n 6 M m N
]f%L"^g _ #T%%& 'F j +^sVx
J R / u y h
s03</q1S=Lr !! "" #@#$`%%o'E N h 1
- 8 e t
D z (
8f,:f=b& b I +!!!$$%%&%&y&$'=''( W/PvPl1WG V C c GUVPg d {$x%%%( l {
w
z ( I !$! 0 5c
U
oXJN3O$%p&&1''" HNl6}~
=+hog """$%) b q
8DN3w @Ij w!!!"''2 y t] @ )
,
3
2
B j(j
@!!!!!!a"###$ %-%v', ou"l
Oavnt06E&)yCv \ o ! &s&&''& Ug9H
D_
& 8"%6&&& d I
wG8 "\$$ }>
a >4_@? [ "$2 g r + u
G
t F H 5h|/# ^!!##% bj t
<dCs x
N"Z$a$R%n&w&"'( OQ`;
;|_2]! % A "#$$&& '. Y } CS:=H% =
r
.
S C "#$!%&'{''' L+:F6z]
%4 7 u ' 7!X!"M# + m k^Y
#[ - n +"I#$K$%&6'''# H! 8
][+DP !
!!"#$%M& u y^
[eze$ '4 ](X 6
^ | k
d)=B lyPeo 4_ , : 3!z"8#j#m###$$%%&j''' 5 ssm
, !!!<"X###$!$%) JU/3
'
{PZ ~ C a!i!"_##J%h&'$ <E z `
+
n"$a@Ma: . R o"P##$%% V x
iZU6O P|7D P + "#& D%C
eVpr @ x !##?$q$$&&&'$ Y[ 4;V w !4"f"-#% &_&& h `
Fy ~ ##/ !Ow
!
h?q@#28V\ `rr | [!#$%&&&& '}' <a1
_12d% _""#$$%t''' B~k
lN* 8 A $H%K&f&&4'2 b? P
?'C"ot-s$&Fp/ p b !}!#c#$ &d&&M'b'4 (ORdx') p O K
-a+ 1 L q!t!!#$'$$&&'6 # 9 .xBo X '
|
bMw] F!m!""#e##V%d%n%d'' [ ? o 0u \ a }#/$5%%&F' T Y=9 4 R
'!E S"*$#%&','5 rE[
A 9DS @R"5 Y = 9 > _ !T!"%&_''''" 'T1
! U p K3R Q i C#v#'( '8Ea7A3 " eh $0ov < E""#R$&&< +Q
V
7
,$n
cU 1 O r 2 !:!!""###$$&0 _ $
ET`s)} /Fez (vR X 5 "#;# $k%&0 y, WRyEVR{b/U j # !"T#p#D$$&O'V'''''8 @ -<gJJ
8
v}Ek;v4Y[ a d }""#'( Ud9
?
Y
AHXko0Hk " - 8 T W "$W&&2 |z) $
G
w % 1 @ O t
(K(AN !""u%}%%%&q'''6 H - F\q3T
<% E r
H J s w
*
1eHu/Lax { & !!$^%9' p H
KY
} ) 2 %w}?v|
= S R`u P V ~ z ! 3 M Q"{##b%I&U&K']''G K q02?Kou %pw
5 L l # > M M
\e
I?-K n p v N x { 0!F#&'G M *V
O 0V U z
Q . b g
/TO<a q !!
# $z$$%$&<'9 s4\Mkp?
(
T 1 Ai'i v!!!!""N$%'0') |Tf8G
Nuv^s/>
"&&+ BN*i$ F
c: r w !M""
#$$$&'') l K G*]95
Zd3 6 O t ! "*"H#L#$d$( 4 WTr. y _
{ j
kx~d9 !2!";"y"O#W#^##$$%' _
hT~5U3 C w } ,#p$'! ANO
^g>1MU#_ Z!^"##G%%&&2 8 S -w'NQXA( o N n &0 ` p!s!")$$4%U%%&'1 7`62 !82d?! h X
8 9!B###&&'' ,f+ 7 j. V !""&D G o ,vE[ $ D #
G 0 I v
)
0dG @M 2 !!!"#$a%t%|%8'p'''J Sjt
$N /U> v y
K S - a tHr.> ;h` /!!!M$#&, k J z
i
94Yj2s v
" " #K#$$o$$&'- R +6M_W 71=0iT> 7 !o!A##%&&'L Q 5DR #
.T u "
F
`
-=i:?_ 1 .!!! "#$s%&'r O P ijkQz !"2' ^_kls>Qf g
E { k |}g '()>;<gh9>c' / 0 h i ,!-!!!!!!!!""###$$$X%Y%f%p%q%r%%%&C&D&z&>''7 lc(dmt?Rq
| ) l M* Hd( c j """g%%%%E&%'?'$ {3O`9 h
~9h?% J H!L!!-""$$Z%%&&{&' lQ3(Sr} m Wd a "B""h%%%( 2%0`Qm2> * Heh "[#|$$$y%%%%%F&&'@'8 Xm)XenuH W
Z D ~
s+ )T < & "4#3$ dw@ d NV !)QI) e k ""I" - D
: @8y_m !g##$'', % ; |m
Da[~ |
/ 2 h &x]; I![%%* m4P^P i
i X { p !.""#$$)%&f' 0:
`OK ) J M!"k$%'&<&|&& ( 6d^)s q ~ : Xp@5jKOw-O 2 # $$$, 1 m4/
64]^e b !
"'""#%4&q& T4
YXr!> #%%%' > ] R
O
V n _{> J C"B$P$$i%&&&'2' Im17Rgn3?b K w"\#}$$%G&* 3#Oa%1< +
FfV ""1$$z%%A& !#~
>iphi #"%"%%' &K p
I, ""$$%%%''A'+ c 8r iX [
A! ' 5#s#$%%'0 JY *Yf
,/EJH # ^ x!!"1#%+&.&9&''& !9v
O4kx
6R = F !!j""%%%&) n-oI
E t9%EW*kUK & l #4$t$R'Y' z ^{ 4
V
WCkf l t ##w'1 AxAA *
e O 2 "J]}k c !"J""#$$%1&O&&H'( e X -
2joR )k* C !!!!"Y"b""$.%7%' u
Z3#*RJ i A!!!s" #(##G$
% vE
AM)7o* !"$%t&&' . w }
b;ou1'\` ] G !"#R&'' #6
_MFzzDw!h#$ &'% pm=^IPw
9Dn p {!!"#''* ({n"E
3 ]
/R !9"y#\%&.'2 E h}M\bi\
0 ^ i
K'E^g' f J!%&# & < :I
T
h{U`< ! #$%&7&& V{
}
]ay %&+ $BQ j
e
r
$
.ri#H| 5 ,$<$]$*% 'g' n [Q
^x 9 q "& `J`
{ 2Y | /"#$>%! e5_-
jcY !"$g$$ %%%$ V
?a `ms* \ Q!""$$$)'C'& X?;;
UH5A N!?"""l$D%(&' ?
b Ms@PeL $!!U"&=&}& ~1~ K "%%%/ 7e,BJ_ $*t g
H
m
Akk ~ ; O%l''B h /NZjt6 c l v
; Yq6TuL[#GI>; hJ$ !$2 ) e s i D [
f r N0 !5!V!_!!2"### $_$) 7
+ P6x.i}P 3 ? "#
$%$&&'- 2 @ 0 S
u ~ Pft_t f y { !("O"b$x$%S%%
'0 k C
7Fe f c ! "%%%x&#' 5
nn??!!"#,%o&. cnt !k
=
`
=C 5D^%B7 [ !7""[$&5&r&&0 PR_a:<G t
;s {g\" @ B #Y$!'' ]
Z"C$y & "$%%&''- \;2 5
& * ] !<?Y }`3^ h!7#l##$%%&i' UZ
Uq6? O e"##>$%&& ; 0
&0n?so) . a !b#$& '3'a'|') " Z ><& W
`\ K [ D l!"##.$"%&''/ &D*DSZ
P
U
o #RTnu< !D""u#Q$$$'4 ? ^ ~ ;TI8
>
r|DU/a 7 T |":#o#C$$j%&&' 2;Gu{r L ( %H&# p)[Jeno7
M& !"E#% MV8Sh4^
5 8 v x"N#]#~$ 7 ,@c-/ 8!Y!#$ n *LuM ,
8/ g !J#$L${%"&&7''. 4P
b&S
=$G8 . """ ",""$%B&' $_2=
S ; % ` H"3#Z#2$$ , l Z\: W o "%;&&'$
]3
9 5?^zqi \,]I &"##$$&' ""$fo
EU ""$"@&( I7, .j G J Q E k !i"0#%%%%%-&'" z
W 1\j h s !!X"" #$%0&N& v
H L[ z!!""$'( D 'z!L[h
]
.J\`
zTf x##% __ q
#
-]h{;$f$=%%%
'
LGr #!>"""$$('B'- d AI#MYsC65 b
e l
*S" !4!!1"# $$&k''# ? j
_ }
em>Bz >!!%%%%- ^9:1Y ) \ > zBfp5x~ g!6#k###%&''3 ! :);Y7
Cm"Q `t[ ( - ; k!{"9#a#n#t#$$ 6 Zdt
, #%( )Kt L ~7
7$ _ !!""G"2#Y#$:&&'1 +yn
y-0 \F I T D H g !" #$"$%%%,&/&! C Zg^ \ - F\ gK "!y!=""#:$$<%'. 9":X05
( Rl!s !f!j!!!`##%) c
Kx [ x}6[ [ 6 S C G !""#$;%%%? VWw4
|5Q 745qr > ? @ A B D E b!c!d!e!!!!"T$:%%%'' b
L
Py28J > F !k"U$@%K%%&[&i&'$ o $%bzb ! / '!l"Q##$%\&j&S''& G.p ! {
, F :pQj3V; L S !p"##1%A%%Z'( Fc
o #u:X}7X9l} ' !5$V$u$$L%- =MJ a
&AFN7&+K m ? G #%%&' py
&e7le8^ E g " (!#$k&&x' | %V{ Q}m % { W
X[cD Q , u m""#### %]&( _/
5
W
.jP#y!cW 0 R#b&T''- zE
; D
R^~s M l y T !K"\""##2%%&&&I'['( 0HBjq&B" B | - G f q W t !!"#i$$$%% 7/ M
!3m#4< A !q"# $@$r$$$%%2&% y +
;PfKpkqW 3 d
!!"#$B%P&&'9 Zg-h S
.
p $SY<m~l d
!!!5"c""W$v$M%&& 5d ;p-8Y- !"g".# &+
G\
Y
nv~5Y*D x X
7
8<?KGz !!###%( v K a
yv&SS'[ "## &&'" PF
8W*9sF s !"=#$$&&&&~' " B)f-*8r $H )!"%%&&- qwx ;
b'yN@ Ap39]} # l \!###l&u&& 'y') "
z
AiV+m af_ h D!"$$&'! = e
&c|&bg|!]~T ^ "##$S& pveRa H !$
&' / a x b}
2
<W22`""##%u'' ~ `3
(xn Z $%'' X |
EG {.R "# %
X7
\* , J$L&5' l
m+#`n+ 9 B - Q !n"i###$I%g&'# XC$B
YdNOo{Exv "#$ &^&&&( `
>kcp$ "1r%Eqo q 7 |!"$%c&e&&$ cn&
Q
/tL ~!#d#$m%&+'E'c'- q0
@ 6
J# 0 ; q 1 ^ !S!!"# %'K cX
@DGV_u|(DQx:Q uz.Ed'3GuX ! , Z S c !#S#$N'U'''* {S|y(q F
< JX_t % z#]%%&J'\''> {oF
4 P k L
0.S , m M p z u!!" ##$&&'/') F))# E
^
bST 2 N B ! !!:"L""+#V#$
%''( Pe* W U r!]""""#($3%F%&&&'6 F IZi# = C
H
(
6GcFXhu 6 n!!#n$$&''4 Cy~N]cjr=Pp !
_ j {L& ^ g G!K!!#W%e%o%% 1k'Y }
r (( "A"""$%* $ : /CC]O } . 1 g 7_Nx^ l #f##j$(%e'' ' = \ . N
p W4=vN= 1
!## $A$%3&& 0;Ja J v"0$$%%'! 8 h $DV5 % " ] r##s$$%&*&8&Q'X') @ U
1Y"inIQ|B b r""'#~#F$$6%&G' | 5 <]^L(nC F !"#%Q&' z
~
S
\
Qg e $&&&-' #ZA
,
d
bqz"1X 4 $+$ %) U W >:
T}lrdP!!T""$%C%&'G h.ik Z
f
Zj=:M
gI} > : U!"^$N%&'0 sR
<
B OmEs$A6 e Z !!6""w$+%&& '% [F \ s
% :T[# N ? d"=$X$%&h'+ %CT
/
q%/TSnm 6 Z ` !!"#-$`'' o (U
q
L . !D# R
<.9R : "!& 6\e2
V 4[ j r W"h"/#?&&'
"
K Gq_ySZ !"w## 9>@HLB4 a
d =AwZ } y =!0"$& B (]
f+E f F""9$$&/ b8aK Z
w
1ZI3p = !!!#S$$9%?%%Z&+ F #9o|
66Wi%| &!!##$0%%' .
- d"x dV] # %a&. /yi6L
: lo 2 s !!![""$h$$$%%1
f4,gA
R
4
km*,X, c !;!7$$$%&'4 `C
W
8
6xu%
BR;>Z ) P 3 ""$####&) :
a@~x(,
UG) k C!""<##$&& ` d
af{ wS Y ##$ & W WA
*"n)m-+ P "I$&E b
%
CFUt{b
0q2DKt
+ Y : 6 R ] R!" #
$$$l%%*'D'. z
E
j IWS o A V $ !""""*#U# %E%''''$ Y<O< N 5z %F6] k 5 @"#m$'%'$ g-
XVCHPM$ 0 I u""&#q##E$)&'P'W'( "@c
[
\Sm|Bc0 O!"$%&/ ;
Y
N~l9LZf M Y ~"#&
JFZ
!V">&/ A = ?K c
8<5V@H{ e %!!!#%Y&( .x3h@
K
9 wt)wAQ= \ b ###~&'1 V@
c
BzwTp1J(l 9 O X "$ &&& ! f M Z
l\ # / ""##%&%' w2:
I(YU
X X& eL b
'IT
. U V W L M N ""##
& 6
qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA & 8
, +
%
)
!
; 2
!
( E / 1 2 2 * ) ' ~ ) 8 ( 4 ( & 8
, +
%
)
!
; 2
!
( E / 1 2 2 * ) ' ~ ) 8 ( 4 ( : f o &j ` @
j @
A
Jz~)pmH+ k + &"A'
< ht $
t e$ [ /X "V'%a U q=sv O '
J)<Y8 O P
?W}_2k/\ YR X / 8 t!"'F'M'V't' - \E
6
h ,
wg
"" ,
N
wJu" ,
w",
,
,
,
,
A ~# $% $ !%W i sH 1
!
E
] B!, L' 'i 8
<
BL,- ' N R"""#%L'k Z:C
"> y s !$x 2
#u' ="5 zY?K E
c
VIm0)-M0 S \ 'P 9
'+ j #" r#`?}"$ tK`z ;"
9 %
x "
2
Z #$u'^& &VM0 _#
S 2 =
*l%
. C $!%'Z
!%2&
Y?K c VM0 m %'sJ [ 8,A o$0U8 U = m!"&}'''
Vm0-M0 < [
< & s
+
1 'i !!!!$%aU
(a$#A 4 +$
06!"$a
* Q #
k Z:!C
"0%P r!C!G C '^ 6_ 6^
[Z# C +"!%'_-h
i
'+Y#<n E x s y !$%_$$% #7O%]
Zdyd$'- P $
+
!!$t
2
@!!!# %z E
Y
IW9Lf $ ' V%_& u]= "&Od) R Y _ q!"'$&_''H
g W?nj ""##V&'wT) <#$&&
s B`$Q%m&v&
kq!"B%g ?##Od) q!'$&RY _ "_'' XHP"&#E$5c oJN* '
) Od) !
$
ETsh/ `R X Y 5 _ q!" $'$$k%&&_''z E
Y
IwWT)9Lf $ <#$&&'?0 a }#5%&F'
U O$&1'j e
iH| ]$ S A !"*#U# %''
IM&' Y"r"'#F$y: ![" R
Ose w$ 'GltE`
V (v" r
$ ]
Mom * !9"<$t&&g' yR
: O.s+ e !["w$!& ')# E
b !L""$' #A
d
q" 4 +$olOvo !'BN$&Bzp1J 9 O
Vrr &&}'dv
c gU8}Pjd | "`YN(Ox{n "#'' z
e l d y (!!5"##v$&& 85V{ %!# +
/ u
L "`%o'+ bkY,<e[Cp n !!<"##Z$%&''sx
J R sq! n~5 !$/%%'g}| d "b<eCp#Z$&'v
c U8Pjd !
$
ETsh/ `X 5 $$k%& #)A#
d
E
bq" 4 !L""$+$' 6e b
".
3; p"# A)7%!,H$ `
>kcp$ "1r%Eqo q 7 |!"$%c&e&& b
%
CFUt{b
0q2DKt
+ Y : 6 R ] R!" #
$$$l%%*'D'!Ow
!
h?q@#28V\ `rr | [!#$%&&&& '}'u y^
[eze$ ' 7`62 !82d?! h X
8 9!B###&&''b? P
?'C"ot-s$&Fp/ p b !}!#c#$ &d&&M'b' o (U
q
L . !D#y t] @ )
,
3
2
B j(j
@!!!!!!a"###$ %-%v'x~I
#
SjWny jQ W ` i " 4 " # $V&'':
a@~x(,
UG) k C!""<##$&&' = \ . N
p W4=vN= 1
!## $A$%3&& ,7&x`6f~@+ 2 I
7 T #
!+S8j2CmQdWj ny bg/j?Q!.P 4 Q W ` h X i " 4 N
8 = V !9!""""" #B#### $V&&&&&&^'''''
' = \ "]"$0f;J. 3
N
o
p 9
W5?^z4qi a=\v,E]N= U 1 I
J !""$"&"v"### $#$0$A$$$%%%3&@&&&''#6
_MFzzDw!h#$ &' " Z ><& W
`\ K [ D l!"##.$"%&'' Xm)XenuH W
Z D ~
s+ )T < & "4#3$.x3h@
K
9 wt)wAQ= \ b ###~&'$p>
v $ ? N R s
'QJ t'.K`w O U z } y | P""T& )Kt L ~7
7$ _ !!""G"2#Y#$:&&'p 7`6H#2
?
b 6
!M82 _sKY
dMF@Pzz?Dew! h L X }
) 8 $!9!!!U"B#h###$& &=&}&&&''' | %V{ Q}m % - !00FivePrimePhosphorylatedFivePrimePhosphorylated
2J
7048be8b-9e28-4f0b-b7b0-14daa5f4e3db
Synthetic
0
pLV3-CMV-Gimap4(mouse)-3×FLAG-Fluc-Puro
1
2017.6.6
2025.9.20
UNA
unspecified
Y K
????? d HO d E Y? P 3
)